Les scientifiques identifient l’origine du cancer grâce à une “chirurgie” cellulaire

Chromosomes Membranes Cellule vivante

Les chromosomes (en rose) sont partagés par le fuseau (en bleu). Les membranes (en vert) sont un facteur de risque pour le partage correct des chromosomes. Crédit : Université de Warwick

Recherche de l’University of Warwick reveals new insights on a key cause of cancer formation during cell division (or mitosis), and points towards potential solutions for preventing it from occurring.

  • When a cell divides abnormally, it does not share the correct number of chromosomes with the two new cells, which can lead to cancer.
  • New research from Warwick Medical School has discovered why and how this happens, using “cell surgery.”
  • Understanding the origin of abnormal cell division and cancer formation may lead to prevention.

When a cell divides normally, it makes a duplicate copy of every chromosome and then shares them equally between the two new cells. This function is carried out by a complex machine in the cell called the mitotic spindle.

If something goes wrong during this stage, the two new cells will be aneuploid, meaning that they will not have the correct number of chromosomes and will make mistakes when sharing genetic information.

Cancer cells are aneuploid, so understanding how and why this happens is incredibly important in finding out how the disease originates.

Professor Stephen Royle’s research team at Warwick Medical School has identified exactly this.

Mitosis Cell Division Process Illustration

Mitosis is the process through which a cell copies its chromosomes and then segregates them, producing two identical nuclei in preparation for cell division. Mitosis is generally followed by equal division of the cell’s content into two genetically identical daughter cells. Credit: NIH

They found that some chromosomes can get lost and trapped in a tangle of membranes that exist in an area around the cell’s spindle, preventing the chromosomes from being shared properly and leading to abnormal cell division that can cause cancer.

They made their discovery by performing a sort of ‘surgery’ on living cells. The researchers invented a way to remove the tangle of membranes in which chromosomes get trapped, and as a result, the chromosomes were rescued by the spindle, thus enabling normal healthy cell division.

This proved, for the first time, that chromosomes getting caught in these membranes is a direct risk factor for the formation of cancerous cells. Understanding this risk can lead to more effective cancer prevention.

Stephen Royle, Professor of Cell Biology at Warwick Medical School, commented:

“Many scientists working on cell division focus on the spindle: how it works and why it makes mistakes in cancer. In this paper we shifted the spotlight and looked at membranes inside dividing cells.”

Dr. Nuria Ferrandiz, lead author of the study, said:

“We found that chromosomes can get trapped in membranes and this is a disaster for the dividing cell. It has the potential to change a normal cell into a cancer cell. Preventing this process may be a way to treat disease.”

Reference: “Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes” by Nuria Ferrandiz, Laura Downie, Georgina P. Starling and Stephen J. Royle, 28 April 2022, Journal of Cell Biology.
DOI: 10.1083/jcb.202203021

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